the consortium
SCREENED brings together nine European universities and companies:
- Universiteit Maastricht (Netherlands)
- Università degli studi di Parma (Italy)
- Université libre de Bruxelles (Belgium)
- Consiglio Nazionale Delle Ricerche (Italy)
- Presens Precision Sensing GmbH (Germany)
- University College Dublin, National University Of Ireland (Ireland)
- Atturos Limited (Ireland)
- ARTTIC SAS (France)
- Cyprotex, an Evotec Company (United Kingdom)
Partners
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Private partners
ARTTIC
ARTTIC assists clients from all business and research sectors, small and large, private and public, to ensure the success of their collaborative research & innovation ventures. During close to 32 years of success, ARTTIC developed and demonstrated expertise in the set-up and management of to date 400 large-scale ambitious projects of which 96 were successful under H2020 calls. Based on its long-standing experience in a range of funding programmes across scientific and technological domains, ARTTIC helps clients to move from strategic plans to effective competitive research and development of innovative solutions, resulting in successful applications and businesses. ARTTIC is a company of the PNO Consultants group, the European leader for consultancy in innovation and funding.
ARTTIC assists clients from all business and research sectors, small and large, private and public, to ensure the success of their collaborative research & innovation ventures. During close to 32 years of success, ARTTIC developed and demonstrated expertise in the set-up and management of to date 400 large-scale ambitious projects of which 96 were successful under H2020 calls. Based on its long-standing experience in a range of funding programmes across scientific and technological domains, ARTTIC helps clients to move from strategic plans to effective competitive research and development of innovative solutions, resulting in successful applications and businesses. ARTTIC is a company of the PNO Consultants group, the European leader for consultancy in innovation and funding.
Universiteit Maastricht
Institute for Technology inspired regenerative medicine (MERLN)
Department of Complex Tissue Regeneration (CTR)
The department holds a prominent international position in the regeneration of vascular, bone and cartilage tissue. CTR was also active in skin regeneration, and most recently it became very active in the generation of regenerative medicine strategies for peripheral nerve repair. The groups’ efforts focus on development of scaffolds, improvement of cell- and growth factor-based tissue engineering, design of high-throughput screening methods and bioreactors with the goal of improving methods for complex tissues and organ regeneration.
The Department of Toxicogenomics represents one of Europe’s leading research teams in the domain of toxicogenomics. Our work emphasizes on in vitro approaches for developing alternatives to current animal toxicity tests, as well as on studying gene-environment interactions in human volunteers, in environmentally exposed groups and patients. The Department of Toxicogenomics is chaired by Prof. Jos Kleinjans and counts 30 scientific employees.
Institute for Technology inspired regenerative medicine (MERLN)
Department of Complex Tissue Regeneration (CTR)
The department holds a prominent international position in the regeneration of vascular, bone and cartilage tissue. CTR was also active in skin regeneration, and most recently it became very active in the generation of regenerative medicine strategies for peripheral nerve repair. The groups’ efforts focus on development of scaffolds, improvement of cell- and growth factor-based tissue engineering, design of high-throughput screening methods and bioreactors with the goal of improving methods for complex tissues and organ regeneration.
The Department of Toxicogenomics represents one of Europe’s leading research teams in the domain of toxicogenomics. Our work emphasizes on in vitro approaches for developing alternatives to current animal toxicity tests, as well as on studying gene-environment interactions in human volunteers, in environmentally exposed groups and patients. The Department of Toxicogenomics is chaired by Prof. Jos Kleinjans and counts 30 scientific employees.
Università degli study di Parma
Re.Mo.Bio.S. lab. has gained long experience in the design and validation of cell culture systems and animal models to realize bioartificial organs, primarily endocrine glands. Since 2005, it is involved in studies on Endocrine-Disrupting Chemicals (EDs) including the effect of PCBs on the thyroid and gonadal axes, in collaboration with the Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico
Re.Mo.Bio.S. lab. has gained long experience in the design and validation of cell culture systems and animal models to realize bioartificial organs, primarily endocrine glands. Since 2005, it is involved in studies on Endocrine-Disrupting Chemicals (EDs) including the effect of PCBs on the thyroid and gonadal axes, in collaboration with the Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico
Université libre de Bruxelles
The laboratory of Sabine Costagliola at ULB was the first to produce functional thyroid cells from mESC. Dr. Costagliola has a tenured government position with an independent laboratory at ULB and she is a highly respected investigator in the field of the thyroid, more specifically as it pertains to thyroid embryonic development and signalling. Her work on the TSH receptor and the generation of fully functional thyroid tissue derived from mESC able to rescue thyroid function in hypothyroid mice, is particularly pertinent to WP3 of this application.
The laboratory of Sabine Costagliola at ULB was the first to produce functional thyroid cells from mESC. Dr. Costagliola has a tenured government position with an independent laboratory at ULB and she is a highly respected investigator in the field of the thyroid, more specifically as it pertains to thyroid embryonic development and signalling. Her work on the TSH receptor and the generation of fully functional thyroid tissue derived from mESC able to rescue thyroid function in hypothyroid mice, is particularly pertinent to WP3 of this application.
CNR
The National Research Council of Italy (CNR – www.cnr.it) is the largest Italian public research organization, counting 109 institutes and more than 6000 researchers. Its mission is to carry out, promote, spread, transfer and improve research activities in the main sectors of knowledge and their applications for the scientific, technological, economic and social development. The institute of CNR involved in SCREENED is the Institute of Science and Technology for Ceramics (ISTEC).
The National Research Council of Italy (CNR – www.cnr.it) is the largest Italian public research organization, counting 109 institutes and more than 6000 researchers. Its mission is to carry out, promote, spread, transfer and improve research activities in the main sectors of knowledge and their applications for the scientific, technological, economic and social development. The institute of CNR involved in SCREENED is the Institute of Science and Technology for Ceramics (ISTEC).
Presens Precision Sensing GmbH
PreSens Precision Sensing GmbH is a young innovative company developing and manufacturing optical sensors, so called optodes. Starting from the niche market of micro-sensors, PreSens is now providing the whole range of products in the field of chemical-optical sensors for various application formats. These include e.g. precise and very robust spot sensors, 2D mapping of analyte distributions via chemical imaging of planar sensors, as well as minimally invasive fibre optic micro-sensors with high spatial resolution.
PreSens Precision Sensing GmbH is a young innovative company developing and manufacturing optical sensors, so called optodes. Starting from the niche market of micro-sensors, PreSens is now providing the whole range of products in the field of chemical-optical sensors for various application formats. These include e.g. precise and very robust spot sensors, 2D mapping of analyte distributions via chemical imaging of planar sensors, as well as minimally invasive fibre optic micro-sensors with high spatial resolution.
University College Dublin, National University Of Ireland
The Pennington biomedical proteomics research group in the UCD Conway Institute has extensive experience of protein discovery in the context of mammalian cell biology and human disease pathology. Their proteomics expertise is directed towards the application of integrated omics data to the identification of (i) functionally significant pathways and networks in diseases through analysis of physiologically relevant perturbations using in vitro cell line systems and (ii) protein biomarkers that support the prediction of responses and stratification of patients from analysis of human clinical material. Expertise in protein biomarkers extends to the development of multiplexed targeted quantitative protein assays.
The Pennington biomedical proteomics research group in the UCD Conway Institute has extensive experience of protein discovery in the context of mammalian cell biology and human disease pathology. Their proteomics expertise is directed towards the application of integrated omics data to the identification of (i) functionally significant pathways and networks in diseases through analysis of physiologically relevant perturbations using in vitro cell line systems and (ii) protein biomarkers that support the prediction of responses and stratification of patients from analysis of human clinical material. Expertise in protein biomarkers extends to the development of multiplexed targeted quantitative protein assays.
Atturos Ltd
Atturos is a recent (Dec 2016) spinout from UCD with a dedicated independent R&D laboratory located in the UCD Conway Institute. Atturos research expertise is focussed on the development and implementation of advanced multiplexed protein biomarker diagnostic tests. Atturos has a pipeline of IP related to new tests in oncology, inflammation and metabolic health. Using multiple reaction monitoring (MRM) liquid chromatography mass spectrometry Atturos exploits its leading-edge expertise to subject these test to analytical and clinical validation and will work with partners to deliver them to clinical utility. Atturos vision is to be a leading global provider of new tests (data and tools) that have a positive impact on human health and wellbeing.
Atturos is a recent (Dec 2016) spinout from UCD with a dedicated independent R&D laboratory located in the UCD Conway Institute. Atturos research expertise is focussed on the development and implementation of advanced multiplexed protein biomarker diagnostic tests. Atturos has a pipeline of IP related to new tests in oncology, inflammation and metabolic health. Using multiple reaction monitoring (MRM) liquid chromatography mass spectrometry Atturos exploits its leading-edge expertise to subject these test to analytical and clinical validation and will work with partners to deliver them to clinical utility. Atturos vision is to be a leading global provider of new tests (data and tools) that have a positive impact on human health and wellbeing.
Cyprotex, an Evotec Company
The Modelling and Simulation Group uses state-of-the-art simulation and pattern recognition modelling systems to predict the responses of humans and other organisms to xenobiotic exposure, including pharmaceuticals, agrochemicals, consumer products and other chemicals. Our areas of expertise include both toxicokinetics (the disposition of compounds in, and elimination from, the body) and toxicodynamics (the response elicited by a xenobiotic) as well as the interactions between these phenomena.
The Modelling and Simulation Group uses state-of-the-art simulation and pattern recognition modelling systems to predict the responses of humans and other organisms to xenobiotic exposure, including pharmaceuticals, agrochemicals, consumer products and other chemicals. Our areas of expertise include both toxicokinetics (the disposition of compounds in, and elimination from, the body) and toxicodynamics (the response elicited by a xenobiotic) as well as the interactions between these phenomena.
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 825745
