Promotional materials
SCREENED POSTER
An insight into what SCREENED is about!
SCREENED BROCHURE
The main challenges in the identification of ED that interfere with the thyroid function and how SCREENED will tackle them !
PUBLICATIONS
2024
A Modular Microfluidic Organoid Platform Using LEGO-Like Bricks; Daniel J. Carvalho, Anna M. Kip, Andreas Tegel, Matthias Stich, Christian Krause, Mírian Romitti, Carlotta Branca, Bart Verhoeven, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht; Advanced Healthcare Materials, Volume 13, 2024. https://doi.org/10.1002/adhm.202303444
Impact of benzo[a]pyrene, PCB153 and sex hormones on human ESC-Derived thyroid follicles using single cell transcriptomics; Marta Nazzari, Mírian Romitti, Anna M Kip, Rick Kamps, Sabine Costagliola, Twan van de Beucken, Lorenzo Moroni, Florian Caiment; Environmental International, Volume 188, 2024. https://doi.org/10.1016/j.envint.2024.108748
2023
CODA: a combo-Seq data analysis workflow; Marta Nazzari et al.; Briefings in Bioinformatics, Volume 24, Issue 1, January 2023, bbac582, https://doi.org/10.1093/bib/bbac582
Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq; Marta Nazzari et al.; Front. Endocrinol., 22 September 2023, Sec. Thyroid Endocrinology, Volume 14 – 2023; https://doi.org/10.3389/fendo.2023.1200211
Clamping strategies for organ-on-a-chip devices; Daniel J. Teixeira Carvalho, Lorenzo Moroni & Stefan Giselbrecht; Nature Reviews Materials Volume 8, pages147–164 (2023); https://doi.org/10.1038/s41578-022-00523-z
Thyroid-on-a-Chip: An Organoid Platform for In Vitro Assessment of Endocrine Disruption; Daniel J. Carvalho et al.; Advanced Healthcare Materials, Volume12, Issue8, March 24, 2023; https://doi.org/10.1002/adhm.202201555
A Computational Template for Three-Dimensional Modeling of the Vascular Scaffold of the Human Thyroid Gland; Giulia Spaletta, et al.; Tissue Engineering Part A, Volume 29, Numbers 1 and 2, 2023; https://doi.org/10.1089/ten.tea.2022.0148
Woven bone formation and mineralization by rat mesenchymal stromal cells imply increased expression of the intermediate filament desmin; Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Giulia Spaletta, Giulia Remaggi, Lisa Elviri, Salvatore Mosca, Silvio Caravelli, Massimiliano Mosca, Roberto Toni; Front. Endocrinol., , Volume 14, 2023. https://doi.org/10.3389/fendo.2023.1234569
Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration; Mirian Romitti, Sabine Costagliola; Endocrinology, Volume 164, Issue 10, 2023. https://doi.org/10.1210/endocr/bqad136
2022
Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism; Mírian Romitti, et al; Nature Communications Volume 13, Article number: 7057 (2022); https://doi.org/10.1038/s41467-022-34776-7
Decellularization Detergents As Methodological Variables in Mass Spectrometry of Stromal Matrices; Giulia Remaggi et al.; Tissue Engineering Part C: Methods, Volume 28, Issue 4, April 2022; https://doi.org/10.1089/ten.tec.2021.0191
2021
Single-Cell Trajectory Inference Guided Enhancement of Thyroid Maturation In Vitro Using TGF-Beta Inhibition; Mírian Romitti, Sema Elif Eski, Barbara Faria Fonseca, Pierre Gillotay, Sumeet Pal Singh, Sabine Costagliola; Frontiers in Endocrinology, Volume 12 (2021). https://doi.org/10.3389/fendo.2021.657195
2020
SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner (project report; download pdf); Lorenzo Moroni, Fulvio Barbaro, Florian Caiment, Orla Coleman, Sabine Costagliola, Giusy Di Conza, Lisa Elviri, Stefan Giselbrecht, Christian Krause, Carlos Mota, Marta Nazzari, Stephen R. Pennington, Annette Ringwald, Monica Sandri, Simon Thomas, James Waddington, Roberto Toni; International Journal of Molecular Sciences, Volume 21, Issue 10 (May 2020). https://doi.org/10.3390/ijms21103648
Microtopography of Immune Cells in Osteoporosis and Bone Lesions by Endocrine Disruptors; Roberto Toni, Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Elia Consolini, Davide Dallatana, Manuela Antoniel, Enrico Quarantini, Marco Quarantini, Sara Maioli, Celeste Angela Bruni, Lisa Elviri, Silvia Panseri, Simone Sprio, Monica Sandri, Anna Tampieri; Frontiers in Immunology, Volume 13 (2020). https://doi.org/10.3389/fimmu.2020.01737
2019
A targeted mass spectrometry method to screen collagen types I-V in the decellularized 3D extracellular matrix of the adult male rat thyroid; Marco Alfieri, Fulvio Barbaro, Elia Consolini, Elena Bassi, Davide Dallatana, Carlo Bergonzi, Annalisa Bianchera, Ruggero Bettini, Roberto Toni, Lisa Elviri; Talanta, Volume 193 (2019). https://doi.org/10.1016/j.talanta.2018.09.087
LATEST CONFERENCES
2024
63rd SOT Annual Meeting and ToxExpo, 10-14 March 2024, Salt Lake City, USA. SCREENED delivered a presentation – Screening for the Influence of Endocrine Disruptors on the Male and Female Thyroid Gland.
26th European Congress of Endocrinology (ECE2024), 11-14 May 2024, Stockholm, Sweden. SCREENED delivered a presentation – In vitro models to study human thyroid development.
Gordon Research Conference on Environmental Endocrine Disruptors, 23-28 Jun 2024, Il Ciocco, Italy. SCREENED delivered a presentation – Exploring the Impact of EDCs and Sex-Hormones on hESC-Derived Thyroid Follicles Using Single Cell Transcriptomics.
Annual meeting of the Italian Society of Biomaterials, 8-10 July 2024, Faenza, Italy. SCREENED delivered a presentation – Chitosan is a natural biomaterial able to favour 3D follicular self-assembly of adult male rat, thyroid stem cells in primary culture: innovations from the Horizon 2020 European SCREENED project.
2023
32nd Symposium and Annual Meeting of the International Society for Ceramics in Medicine, 20-23 Sep 2023, Venice, Italy. SCREENED gave a keynote lecture, Innovations from the Horizon 2020 European SCREENED project: iron-doped hydroxyapatite nanoparticles (FeHA NPs) for magnetic guidance of rat thyrocytes onto thyroid lobe-like 3D collagen scaffolds.
12th World Congress (WC12) on Alternatives and Animal Use in the Life Sciences, 27-31 August 2023, Niagara Falls, Canada: SCREENED was represented at this event and Daniel Carvalho from project partner Maastricht University presented a poster on Thyroid organoid-on-a-chip batteries for screening endocrine disruption.
World Summit MPS 2023, 26-30 June 2023, Berlin, Germany: SCREENED actively participated in the conference and presented project results in a talk held by Daniel Carvalho from Maastricht University, with the following title: Thyroid-on-a-chip: an In Vitro Organoid Device to Test Thyroid Disruption.
ENDO2023, 15-18 June 2023, Chicago, USA: SCREENED partner Université libre de Bruxelles had the privilege to be invited to this conference to hold a talk on the Emerging technologies to model the thyroid.
EURION Annual Meeting, 20-21 January 2023, VU Amsterdam, Netherlands: As partner of the European Cluster to improve identification of endocrine disrupters, SCREENED was represented by several project partners and actively contributed with a highlight presentation on the latest results of the project, given by Project Coordinator Lorenzo Moroni (Maastricht University), as well as with two posters:
- H2020 SCREENED: Modelling the alteration of thyroid function on exposure to chemicals, by Prakash Patel, Cyprotex.
- Investigation of the epigenetic effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq, by Marta Nazzari, Maastricht University. This poster was also selected for a spotlight presentation.
32nd Symposium and Annual Meeting of the International Society for Ceramics in Medicine, 20-23 September 2023, Venice, Italy: At this event, a keynote lecture on Innovations from the Horizon 2020 European SCREENED project: iron-doped hydroxyapatite nanoparticles (FeHA NPs) for magnetic guidance of rat thyrocytes onto thyroid lobe-like 3D collagen scaffolds was given by Roberto Toni from SCREENED partner Parma University.
2022
Statistic Seminar 2022, Department of Statistical Sciences, University of Bologna, Italy. SCREENED delivered a presentation – The Horizon 2020 SCREENED Project 825475: High dimensional data for endocrine disruptor assays on thyroid organoids.
44th Annual Meeting of the European Thyroid Association, 10-13 Sep 2022, Brussels, Belgium. SCREENED delivered a presentation – Generation of human thyroid organoids from embryonic stem cells to rescue hypothyroidism.
Research Day, Department of Medicine and Surgery – National Health System, 7 Oct 2022, University of Parma, Italy. SCREENED delivered a presentation – An innovative European Joint Research Centre – Submitted in vitro assay for screening endocrine disruptors effects on thyroid cells function: Horizon 2020 Project #825745.
III Encontro Brasileiro e IV Simpósio de Atualização de Desreguladores Endócrinos, 9-12 Oct 2022, Universidade Federal do Rio de Janeiro (UFRJ), Brazil. SCREENED delivered a presentation – Thyroid organoids as model to study endocrine disruptors toxic effects.
19th International Congress of Developmental Biology, 16-20 Oct 2022, Albufeira, Portugal. SCREENED presented the poster Insulin orchestrates thyroid and lung cell lineage divergence in human stem cell-derived organoids.
PRESS CLIPPINGS
Test sulla tiroide umana grazie a modelli 3D: Un docente di UNIBO partecipa al progetto SCREENED. UNIBO Magazine (06/02/2019).
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 825745
